What are corneocytes?

Corneocytes are specialized cells found in the outermost layer of the skin, specifically the stratum corneum of the epidermis. These cells are crucial for maintaining the skin’s barrier function. They are flat, dead cells that are tightly packed together, creating a protective layer that prevents water loss and shields underlying tissues from pathogens and environmental damage.

The function of corneocytes as a form of cellular glue stems from their structural role in maintaining the integrity and cohesion of the skin. They are embedded in a lipid matrix, which enhances their barrier properties and helps retain moisture within the skin, essential for healthy skin function. This property is paramount because it assists in keeping the skin hydrated and protects against irritants.

In contrast, cells that produce melanin are responsible for skin pigmentation and protection against UV radiation. Cells that promote the regeneration of skin play a role in healing and repair processes, while those that facilitate the transport of nutrients are more associated with vascular structures rather than the epidermis. Thus, the choice highlighting the role of corneocytes as cellular glue reflects their critical structural and functional attributes in the stratum corneum.